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Zebrafish models are gaining recognition in their applications within several fields, such as developmental biology and toxicology. The advantages of the zebrafish model are mainly its low cost and ease of maintenance and breeding. Moreover, the zebrafish is ideal for research purposes due to its small size, ease of handling and transparency. 

Taking advantage of this embryo transparency, we can test the toxicity of pharmacological, agrochemical and cosmetic compounds to the innate and adaptive immune system by quantifying these cell populations. 

We have in-house zebrafish transgenic lines specific for neutrophils (Mpx-GFP, Renshaw et al., 2006) and for macrophages (Mpeg-mcherry, Ellet et al., 2011). 

Additionally, this model can also be used to identify new anti-inflammatory compounds, by following leukocyte recruitment to inflammation induced by sterile tissue injury.

Vendor: Biobide